Neal E Slatkin Selected Research

Opioid-Induced Constipation

1/2022	First-Dose Efficacy of Methylnaltrexone in Patients with Severe Medical Illness and Opioid-Induced Constipation: A Pooled Analysis.
9/2021	The influence of brain metastases on the central nervous system effects of methylnaltrexone: a post hoc analysis of 3 randomized, double-blind studies.
6/2021	Correction to: The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation.
1/2021	The Influence of Age on Central Effects of Methylnaltrexone in Patients with Opioid-Induced Constipation.
1/2021	Attrition of methylnaltrexone treatment-emergent adverse events in patients with chronic noncancer pain and opioid-induced constipation: a post hoc pooled analysis of two clinical trials.
1/2021	Subcutaneous Methylnaltrexone for Treatment of Opioid-Induced Constipation in Cancer versus Noncancer Patients: An Analysis of Efficacy and Safety Variables from Two Studies.
3/2020	Subcutaneous methylnaltrexone for opioid-induced constipation in advanced-illness patients with or without active cancer.
1/2019	Safety of oral methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain.
1/2017	Randomized, Double-Blind Trial of Oral Methylnaltrexone for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain.
7/2015	Efficacy and Tolerability of Subcutaneous Methylnaltrexone in Patients with Advanced Illness and Opioid-Induced Constipation: A Responder Analysis of 2 Randomized, Placebo-Controlled Trials.

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Neal E Slatkin Research Topics

Disease

15	Pain (Aches) 01/2022 - 01/2003
12	Opioid-Induced Constipation 01/2022 - 05/2008
10	Neoplasms (Cancer) 01/2022 - 01/2003
5	Nausea 01/2021 - 05/2007
4	Constipation 01/2021 - 05/2008
4	Cancer Pain 05/2010 - 11/2003
3	Substance Withdrawal Syndrome (Withdrawal Symptoms) 09/2021 - 03/2020
3	Abdominal Pain (Pain, Abdominal) 01/2019 - 11/2011
2	Vomiting 01/2021 - 05/2007
2	Breakthrough Pain 07/2010 - 07/2007
2	Chronic Pain 09/2009 - 07/2007
2	Breast Neoplasms (Breast Cancer) 09/2005 - 01/2004
1	Brain Neoplasms (Brain Tumor) 09/2021
1	Dementia (Dementias) 01/2021
1	Stroke (Strokes) 01/2021
1	Cardiotoxicity 01/2019
1	Diarrhea 01/2019
1	Flatulence 07/2015
1	Muscle Cramp (Cramp) 11/2011
1	Body Weight (Weight, Body) 05/2008
1	Dizziness (Lightheadedness) 07/2007
1	Fatigue 07/2007
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2004
1	Mucositis 09/2003
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 09/2003
1	Sleepiness 05/2003
1	Sleep Initiation and Maintenance Disorders (Insomnia) 05/2003
1	Weight Loss (Weight Reduction) 05/2003
1	Alzheimer Disease (Alzheimer's Disease) 05/2003
1	Death (Near-Death Experience) 01/2003
1	Intractable Pain 01/2003

Drug/Important Bio-Agent (IBA)

13	Opioid Analgesics (Opioids)IBA 01/2022 - 07/2007
12	methylnaltrexone FDA Link 01/2022 - 05/2008
4	Narcotic Antagonists (Opioid Antagonists)IBA 09/2021 - 01/2017
4	Morphine (MS Contin)FDA LinkGeneric 01/2021 - 07/2015
3	LaxativesIBA 01/2022 - 01/2019
3	Opiate AlkaloidsIBA 09/2003 - 01/2003
2	Opioid Receptors (Opioid Receptor)IBA 01/2021 - 05/2008
2	TabletsIBA 07/2010 - 07/2007
2	Fentanyl (Sublimaze)FDA LinkGeneric 07/2010 - 07/2007
2	Paclitaxel (Taxol)FDA LinkGeneric 09/2005 - 01/2004
2	Ketamine FDA LinkGeneric 11/2003 - 09/2003
1	Analgesics (Analgesic Drugs)IBA 01/2021
1	Oxymorphone (Numorphan)FDA LinkGeneric 05/2010
1	Dopamine AntagonistsIBA 05/2007
1	CannabinoidsIBA 05/2007
1	Serotonin (5 Hydroxytryptamine)IBA 05/2007
1	Neurotransmitter Agents (Neurotransmitter)IBA 05/2007
1	Neuroprotective AgentsIBA 01/2004
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2004
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2004
1	Amifostine (Ethyol)FDA LinkGeneric 01/2004
1	Methylphenidate (Ritalin)FDA LinkGeneric 05/2003
1	AcetylcholinesteraseIBA 05/2003
1	Donepezil (Aricept)FDA LinkGeneric 05/2003
1	Phenol (Carbolic Acid)FDA Link 01/2003

Therapy/Procedure

7	Analgesia 01/2022 - 07/2007
3	Therapeutics 07/2010 - 09/2008
2	Pain Management 01/2021 - 01/2003
1	Palliative Care (Palliative Therapy) 09/2008
1	Drug Therapy (Chemotherapy) 05/2007
1	Radiotherapy 09/2003